Proliferating cell nuclear antigen and p53 protein expression in submucosal invasive colorectal carcinoma.
|Sustaining proliferative signaling|
To characterize submucosal invasive colorectal carcinoma, we investigated expression of PCNA and p53 protein. The PCNA labeling index (PCNA-LI) is determined at the deepest lesion of carcinoma. The expression of PCNA and p53 protein were analyzed according to clinicopathological factors. 2) The flat type had significantly higher PCNA-LI (65.1+/-8.2%) and p53 protein expression (69.6%) than the polypoid type. Our results suggest that in order to determine the treatment for the patients with submucosal invasive colorectal carcinoma, the expression of PCNA and p53 protein may be a useful biologic marker.