17 beta-estradiol activates PI3K/Akt signaling pathway by estrogen receptor (ER)-dependent and ER-independent mechanisms in endometrial cancer cells.
P-Akt/Akt was used as a measure of activation of Akt.
Current perspectives on Akt Akt-ivation and Akt-ions.
Getting in on the Akt.
Assays for Akt.
Getting into the AKT.
Both Akt and phosphorylated Akt (phospho-Akt) were present in ESC.
[Inhibitory effect of lentiviral vector-mediated SHIP gene transfection on proliferation of leukemia K562 cells and PI3K/Akt pathway regulation].
The expression of SHIP, Akt, and phosphorylated Akt (p-Akt) was detected by Western blot.
[Activation and significance of the PI3K/Akt pathway in endometrium with polycystic ovary syndrome patients].
The expression of Akt and phosphorylated Akt (p-Akt) were determined by western blot.
Mesangial medium from IgA nephropathy patients induces podocyte epithelial-to-mesenchymal transition through activation of the phosphatidyl inositol-3-kinase/Akt signaling pathway.
Phosphorylation of Akt increased with this medium, as indicated by an increase in the p-Akt/Akt ratio.
Early endosomal antigen 1 (EEA1) is an obligate scaffold for angiotensin II-induced, PKC-alpha-dependent Akt activation in endosomes.
Both Akt and phosphorylated Akt (p-Akt) interact with EEA1.
AKT crystal structure and AKT-specific inhibitors.
Phosphorylated PDK1 is an activator of Akt by phosphorylating Akt.
Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models.
This neuroprotection was accompanied by increased Akt phosphorylation (p-Akt).
Curcumin inhibits cellular condensation and alters microfilament organization during chondrogenic differentiation of limb bud mesenchymal cells.
Curcumin suppressed the phosphorylation of Akt leading to Akt inactivation.
Chronic Akt activation attenuated lipopolysaccharide-induced cardiac dysfunction via Akt/GSK3beta-dependent inhibition of apoptosis and ER stress.
Akt overexpression promoted phosphorylation of Akt and GSK3beta.
Characterization of fenofibrate-mediated anti-proliferative pro-apoptotic effects on high-grade gliomas and anti-invasive effects on glioma stem cells.
Phosphorylation of Akt was also diminished, with no change in total Akt.
Akt destabilizes p57 (Kip2) : Akt at the converging crossroad?
Inhibition of Akt by the Akt-inhibitor-VIII had no effect.
Erythropoietin enhances mitochondrial biogenesis in cardiomyocytes exposed to chronic hypoxia through Akt/eNOS signalling pathway.
Blocking Akt was associated with the decreased phosphorylation of Akt and eNOS.
The expression of Akt and P-Akt was detected by Western blot.
Oleanolic acid supplement attenuates liquid fructose-induced adipose tissue insulin resistance through the insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt signaling pathway in rats.
In contrast, phosphorylated Akt to total Akt ratio was increased.
Frequent and increased expression of human METCAM/MUC18 in cancer tissues and metastatic lesions is associated with the clinical progression of human ovarian carcinoma.
The phospho-AKT/AKT ratio was elevated in metastatic lesions.
Exercise effects on muscle beta-adrenergic signaling for MAPK-dependent NKCC activity are rapid and persistent.
This Akt activation was unaffected by isoproterenol.
Human follicle-stimulating hormone (FSH) receptor interacts with the adaptor protein APPL1 in HEK 293 cells: potential involvement of the PI3K pathway in FSH signaling.
In addition, FSHR coimmunoprecipitates with Akt.
AKT is a downstream target of PI3K.
Cholesterol feeding reduces vascular endothelial growth factor signaling in rabbit corporal tissues.
Akt, p-Akt, and p-Akt/Akt were measured by enzyme-linked immunosorbent assay.
Akt signaling and growth of the heart.
Putting the rap on Akt.
The Akt of translational control.
Desferoxamine and ethyl-3,4-dihydroxybenzoate protect myocardium by activating NOS and generating mitochondrial ROS.
NOS is activated by Akt.
Akt catalytic activity is required.
Does cytoskeleton 'Akt' in apoptosis?
Phosphorylation of HDM2 by Akt.
Akt as a mediator of cell death.
PI3-kinase regulates survival of chronic lymphocytic leukemia B-cells by preventing caspase 8 activation.
Akt was found to be activated.
Inhibition of angiogenesis by vitamin D-binding protein: characterization of anti-endothelial activity of DBP-maf.
However, Akt activation was not affected.
Determination of Akt/PKB signaling.
EGFR is required for Akt activation.
Ketamine decreased Akt phosphorylation.
Human intestinal epithelial cell survival and anoikis. Differentiation state-distinct regulation and roles of protein kinase B/Akt isoforms.
Expression/activation parameters of Akt isoforms (Akt-1, Akt-2, and Akt-3) and Fak were analyzed.
Phosphorylated Akt in prostate carcinoma.
Epidermal growth factor protects epithelial cells against Fas-induced apoptosis. Requirement for Akt activation.
Requirement for Akt activation.
Phosphatidylcholine biosynthesis via CTP:phosphocholine cytidylyltransferase 2 facilitates neurite outgrowth and branching.
CTbeta2 was not phosphorylated in vitro by Akt.
AKT and cancer--is it all mTOR?
The two TORCs and Akt.
Akt/protein kinase B.
mTORC2 Caught in a SINful Akt.
Targeting Akt in cancer therapy.
Akt as a therapeutic target in cancer.
STAT3 activation in photoreceptors by leukemia inhibitory factor is associated with protection from light damage.
Akt was not activated by LIF.
Cell proliferation and drug resistance in hepatocellular carcinoma are modulated by Rho GTPase signals.
In contrast, AKT activation was not altered.
Adrenergic receptor agonists prevent bile duct injury induced by adrenergic denervation by increased cAMP levels and activation of Akt.
This was associated with enhanced phosphorylation of Akt.
Akt demoted in glioblastoma.
Agrobacterium-mediated transformation of oat (Avena sativa L.) cultivars via immature embryo and leaf explants.
Akt transformed with nos::nptII.
The phosphoinositide 3-kinase/Akt pathway is essential for the retinoic acid-induced differentiation of F9 cells.
This effect is followed by an inhibition of Akt.
Diabetes: caught in the Akt?
AKT in thyroid tumorigenesis and progression.
Chelerythrine treatment influences the balance of pro- and anti-apoptotic signaling pathways in the remote myocardium after infarction.
Akt- and Bad-phosphorylation was unchanged.
Improved rat steatotic and nonsteatotic liver preservation by the addition of epidermal growth factor and insulin-like growth factor-I to University of Wisconsin solution.
AKT was inhibited pharmacologically.
Delineating the signals by which repetitive deformation stimulates intestinal epithelial migration across fibronectin.
Blocking AKT did not.
Discovery of pyrrolopyrimidine inhibitors of Akt.
FGF21 is an Akt-regulated myokine.
Metastasis and AKT activation.
Role of AKT-glycogen synthase kinase axis in monocyte activation in human beings with and without type 2 diabetes.
This effect was blocked by AKT inhibition.
Involvement of Akt in neurite outgrowth.
Substrate selectivity APPLies to Akt.
However, Akt phosphorylation was impaired.
Temporal changes in myocardial salvage kinases during reperfusion following ischemia: studies involving the cardioprotective adipocytokine apelin.
Akt activity was also measured.
AKT signaling in regulating angiogenesis.
Inhibitor hijacking of Akt activation.
Akt in the pathogenesis of COPD.
[Study on signal transduction pathway in differentiation and apoptosis of leukemia cells induced by heat shock protein inhibitor].
AKT is a client protein of HSP90.
Akt and mRNA translation by interferons.
Metastasis and AKT activation.
Chemosensitisation by manganese superoxide dismutase inhibition is caspase-9 dependent and involves extracellular signal-regulated kinase 1/2.
Akt activation was not affected.
AKT signaling in physiology and disease.
The preserved Akt phosphorylated Bad.
Akt in ischemia and reperfusion.
AKT can be activated in the nucleus.
In contrast, AKT was not modulated by sorafenib.
[Relationship between apoptosis and activity of protein kinase B in adrenocortical cells induced by cadmium chloride].
Meanwhile, PKB/Akt is decreased.
Skp2: caught in the Akt.
Triptolide inactivates Akt and induces caspase-dependent death in cervical cancer cells via the mitochondrial pathway.
Conversely, it was attenuated by Akt overexpression.
The PKB/AKT pathway in cancer.
Suppression of DNA-PKcs enhances FGF-2 dependent human endothelial cell proliferation via negative regulation of Akt.
This was associated with an increase in phosphorylated Akt.
Protein phosphatase 2A isoforms utilizing Abeta scaffolds regulate differentiation through control of Akt protein.
Abeta bound Akt.
Akt/mTOR signalling in myelination.
Involvement of the ERK pathway in the protective effects of glycyrrhizic acid against the MPP+-induced apoptosis of dopaminergic neuronal cells.
However, pre-treatment with GA had no effects on the expression of phosphorylated AKT (p-AKT) and total AKT (t-AKT).
Category I AKT is effective.
Gender-related difference of sevoflurane postconditioning in isolated rat hearts: focus on phosphatidylinositol-3-kinase/Akt signaling.
The protein expression of total Akt (t-Akt) and phosphorylated Akt (Ser(473)) (p-Akt) were determined by Western blot.
Critical analysis of simultaneous blockage of histone deacetylase and multiple receptor tyrosine kinase in the treatment of prostate cancer.
The non-responsiveness of Akt
The Paradox of Akt-mTOR Interactions.
Panax notoginseng saponins improve erectile function through attenuation of oxidative stress, restoration of Akt activity and protection of endothelial and smooth muscle cells in diabetic rats with erectile dysfunction.
Expression of Akt was detected by immunohistochemistry.
Activation of Akt and MAPK was inhibited.
Fibroblast growth factors 7 and 10 are involved in ameloblastoma proliferation via the mitogen-activated protein kinase pathway.
However, Akt was not phosphorylated.