Tissue distribution of the P2X7 receptor.
The P2X7 receptor is a bifunctional molecule.
Novel P2X7 receptor antagonists.
[Detection of P2z/P2x7 receptors].
P2X4 and P2X7 puringeric receptors.
P2X7 receptors in the nervous system.
A role for P2X7 in microglial proliferation.
The role of P2X7 in pain and inflammation.
The P2X7 receptor as a therapeutic target.
In this study, the P2X7-mediated cytotoxicity in different type of cells (P2X7(-), P2X7(+) with calcium response, and P2X7(+) without calcium response) was investigated.
P2X7 receptor and apoptosis.
Thus, experiments employing P2X7 siRNA and inhibitors supported an involvement of P2X7.
Lymphocytes from P2X7-deficient mice exhibit enhanced P2X7 responses.
The P2X7 carboxyl tail is a regulatory module of P2X7 receptor channel activity.
The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease.
In all experiments, involvement of P2X7 was verified using established P2X7 antagonists.
Peritumoral P2X7 expression was significantly higher than intratumoral P2X7 expression.
Targeting the P2X7 receptor in rheumatoid arthritis: biological rationale for P2X7 antagonism.
P2X7 receptors and apoptosis in tuberculosis infection.
Extracellular ATP and P2X7 receptors in neurodegeneration.
P2X7 polymorphism and chronic lymphocytic leukaemia.
Agonists and antagonists acting at P2X7 receptor.
Regulation of immune response by P2X7 receptor.
Molecular probes for P2X7 receptor studies.
P2X7-mediated chemoprevention of epithelial cancers.
Orthodontic mechanotransduction and the role of the P2X7 receptor.
Genetics of the P2X7 receptor and human disease.
The role of the purinergic P2X7 receptor in inflammation.
P2X7 is important in inflammation and tissue injury.
Is pannexin the pore associated with the P2X7 receptor?
P2X7 receptors: channels, pores and more.
The effect of anions on the human P2X7 receptor.
P2X7 A1513 polymorphisms and tuberculosis susceptibility.
The role of the P2X7 receptor in infectious diseases.
P2X7 receptor antagonism in the treatment of cancers.
P2X7 expression was determined by immunoblotting and immunocytochemistry.
The immunoreactivity for Panx1 was stronger than that for P2X7.
The P2X7-j interacted with the full-length P2X7 in a manner suggesting heterooligomerization and blocked the P2X7-mediated actions.
We fused P2X7 receptors with enhanced green fluorescent protein (EGFP) at the amino or carboxy termini (EGFP-P2X7 and P2X7-EGFP).
Experiments employing P2X7 siRNA and HEK293 cells heterologously expressing P2X7 and in vivo experiments further supported an involvement of P2X7.
A truncated P2X7 receptor variant (P2X7-j) endogenously expressed in cervical cancer cells antagonizes the full-length P2X7 receptor through hetero-oligomerization.
Second, experiments using P2X7-/- mice, immunohistochemistry, and electron microscopy showed that the antigen detected by frequently used P2X7 antibodies is not compatible with a plasmalemmal P2X7 ...
NF279 fully blocked human P2X7 receptors, but only partially blocked BALB/c P2X7 receptors and was inactive at C57BL/6 P2X7 receptors.
BzATP, a P2X7 agonist, decreased the viability, while P2X7 antagonist oxATP or P2X7 siRNA reversed the viability of PC12 cells under the condition of OGD.
Then, we compared the proliferation rates of B16 melanoma wild-type cells and B16 P2X7 receptor-knockdown clone (P2X7-KDC) cells in the presence of P2X7 agonists.
The growth and neoangiogenesis of P2X7-expressing tumors was blocked by intratumoral injection of the VEGF-blocking antibody Avastin (bevacizumab), pharmacologic P2X7 blockade, or P2X7 silencing ...
Cloning and functional characterisation of the mouse P2X7 receptor.
Blockade of human P2X7 receptor function with a monoclonal antibody.
Expression of the P2X7-receptor subunit in neurons of the rat retina.
Gene structure and chromosomal localization of the human P2X7 receptor.
Effects of antagonists at the human recombinant P2X7 receptor.
In addition, P2X7 mRNA is present in B and T lymphocytes.
Proteomic and functional evidence for a P2X7 receptor signalling complex.
Activation of the P2X7 receptor resulted in its dephosphorylation.
We confirmed, by immunocytochemistry, the presence of P2X4 and P2X7 protein.
P2Z/P2X7 receptor-dependent apoptosis of dendritic cells.
Expression of a P2X7 receptor by a subpopulation of human osteoblasts.
Several observations indicated that the P2X7 receptor mediated this effect.
Tenidap enhances P2Z/P2X7 receptor signalling in macrophages.
Ionic effects on human recombinant P2X7 receptor function.
Reanalysis of P2X7 receptor expression in rodent brain.
The P2X7 ATP receptor in the kidney: a matter of life or death?
In the GCL, most of the ganglion cells showed P2X7 immunoreactivity.
The P2X7 receptor of CLL lymphocytes-a molecule with a split personality.
Association of a polymorphism in the P2X7 gene with tuberculosis in a Gambian population.
Pore formation is not associated with macroscopic redistribution of P2X7 receptors.
P2X7 receptors and UTP-activated receptors mediated these effects.
P2X7 receptors stimulate AKT phosphorylation in astrocytes.
To detect the P2z/P2x7 receptors of human leukocytes.
THP-1 cells have P2z/P2x7 receptors.
No anti-P2X7 immunoreactivity was observed on DRG neurons.
Synaptic localization of P2X7 receptors in the rat retina.
Identification of Thr283 as a key determinant of P2X7 receptor function.
Kinetics of P2X7 receptor-operated single channels currents.
Properties of presynaptic P2X7-like receptors at the neuromuscular junction.
P2X7-related modulation of pathological nociception in rats.
Establishment of an assay for P2X7 receptor-mediated cell death.
The P2X7 nucleotide receptor mediates skeletal mechanotransduction.
These findings are important in the search for allosteric modulators of the P2X7 receptor.
Pharmacological characterization of P2X7 receptors in rat peritoneal cells.
The antibiotic polymyxin B modulates P2X7 receptor function.
This strongly suggested that P2X7 receptors in theca cells are functional.
Functional P2X7 receptors are expressed on osteoblasts in situ and in vitro.
The Western blotting showed the expression of P2X7 and P2Y11 receptors.
Human rheumatoid synoviocytes express functional P2X7 receptors.
The expression of the P2X7 receptor was confirmed by Western blot analysis.
Novel P2X7 receptor antagonists ease the pain.