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Inducing angiogenesis
[The expression of tumor suppressor gene PTEN protein and focal adhesion kinase in salivary adenoid cystic carcinoma and its significance].
PURPOSE:
To investigate the expression of focal adhesion kinase(FAK) and PTEN in salivary adenoid cystic carcinoma (SACC) and its significance.
METHODS:
The expression levels of FAK and PTEN in 50 cases of SACC were detected by strepravidin-peroxidase immunohistochemical technique. SPSS10.0 software was used for Chi-square test, paried Student t test and correlation analysis.
RESULTS:
The expressions of FAK in salivary adenoid cystic carcinoma was 94%, and the negative expressions of PTEN was 70%.There was a significant difference between normal salivary gland and salivary adenoid cystic carcinoma (P<0.01). A significant negative relation was found between the expression intensity of FAK protein and PTEN protein(P<0.01).No correlation between the expression intensity in cribriform,tubular, and solid group was found.
CONCLUSIONS:
Activation of FAK may play a strong role in the development of SACC. PTEN was abnormally expressed in SACC. No significant different expression of FAK and PTEN were found in different clinic pathological types.