Autotaxin and lysophospholipids in rheumatoid arthritis.
Autotaxin in liver fibrosis.
A 3D view of autotaxin.
Autotaxin inhibitors: a patent review.
Autotaxin in embryonic development.
Autotaxin: a protein with two faces.
Chemical evolution of autotaxin inhibitors.
Autotaxin, tumor motility-stimulating exophosphodiesterase.
Measurement of autotaxin/lysophospholipase D activity.
Development of an activity-based probe for autotaxin.
Molecular pharmacology of adipocyte-secreted autotaxin.
Optimization of a pipemidic acid autotaxin inhibitor.
Exocrine pancreatic carcinogenesis and autotaxin expression.
Characterization of non-lipid autotaxin inhibitors.
Autotaxin and LPA receptor signaling in cancer.
Increased autotaxin activity in multiple sclerosis.
Expression of autotaxin mRNA in human hepatocellular carcinoma.
[A study on expression of autotaxin mRNA in hepatocellular carcinoma].
Developmental expression analysis of murine autotaxin (ATX).
Autotaxin expression in non-small-cell lung cancer.
Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate.
Expression, regulation and function of autotaxin in thyroid carcinomas.
Lysophospholipids in the limelight: autotaxin takes center stage.
Cyclic phosphatidic acid is produced by autotaxin in blood.
Autotaxin is a member of the phosphodiesterase family of enzymes, (NPP2).
Reduced expression of autotaxin predicts survival in uveal melanoma.
Regulation and biological activities of the autotaxin-LPA axis.
[Secretion and role of autotaxin and lysophosphatidic acid in adipose tissue].
Autotaxin enzyme immunoassay in human cerebrospinal fluid samples.
[Clinical introduction of lysophosphatidic acid and autotaxin assays].
Therapeutic potential of autotaxin/lysophospholipase d inhibitors.
There is almost no pharmacological tools available to study autotaxin.
None of them have been tested on autotaxin activity.
Autotaxin and lipid signaling pathways as anticancer targets.
Novel point mutations attenuate autotaxin activity.
Autotaxin--an LPA producing enzyme with diverse functions.
Autotaxin inhibitors: a perspective on initial medicinal chemistry efforts.
[Significance of serum autotaxin activity in gastrointestinal disease].
Discovery and optimization of boronic acid based inhibitors of autotaxin.
Pulmonary autotaxin expression contributes to the pathogenesis of pulmonary fibrosis.
Stat3 mediates expression of autotaxin in breast cancer.
Autotaxin controls caudal diencephalon-mesencephalon development in the chick.
Autotaxin protects microglial cells against oxidative stress.
Serum autotaxin is not a useful biomarker for ovarian cancer.
Structure-function relationships of autotaxin, a secreted lysophospholipase D.
Increased stromal autotaxin expression was found in 16.3 % of the tumors.
[Function and biological activities of the autotaxin-LPA axis].
Insights into autotaxin: how to produce and present a lipid mediator.
Autotaxin as a novel serum marker of liver fibrosis.
Aromatic phosphonates inhibit the lysophospholipase D activity of autotaxin.
Decrease in circulating autotaxin by oral administration of prednisolone.
Structural basis of substrate discrimination and integrin binding by autotaxin.
Elevated serum autotaxin was correlated with hepatic dysfunction in BA.
Inhibition of plasma autotaxin activity correlated with inhibition of autotaxin at the site of inflammation and in ex vivo whole blood.
Strong desmoplastic stromal reaction was more frequent among the carcinomas with autotaxin-positive tumor cells or autotaxin-positive stroma.
We found, however, that while autotaxin was efficiently secreted into the extracellular space both in vitro and in vivo, it was expressed neither on the surfaces of autotaxin-transfected cells nor ...
The role of autotaxin and other motility stimulating factors in the regulation of tumor cell motility.
Stimulation of tumor cell motility linked to phosphodiesterase catalytic site of autotaxin.
Autotaxin is an exoenzyme possessing 5'-nucleotide phosphodiesterase/ATP pyrophosphatase and ATPase activities.
Cloning, chromosomal localization, and tissue expression of autotaxin from human teratocarcinoma cells.
Three members have been identified, PC-1, B10 and autotaxin.
Autotaxin (NPP-2), a metastasis-enhancing motogen, is an angiogenic factor.
Expression and transcriptional regulation of the PD-Ialpha/autotaxin gene in neuroblastoma.
Autotaxin (ATX) is a newly found autocrine tumor cell motility-stimulating factor.
Retinoic acid-induced expression of autotaxin in N-myc-amplified neuroblastoma cells.
Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein.
Autotaxin (ATX), a purified autocrine motility factor, was also used as a chemoattractant.
This result is surprising, as there was previously no indication that autotaxin could act as a phospholipase.
Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate.
Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells.
The hydrolysis of lysophospholipids and nucleotides by autotaxin (NPP2) involves a single catalytic site.
Proteolytic maturation and activation of autotaxin (NPP2), a secreted metastasis-enhancing lysophospholipase D.
The N-terminal hydrophobic sequence of autotaxin (ENPP2) functions as a signal peptide.
Autotaxin expression is enhanced in frontal cortex of Alzheimer-type dementia patients.
Phosphodiesterase-Ialpha/autotaxin: a counteradhesive protein expressed by oligodendrocytes during onset of myelination.
Autotaxin (ATX) is a strong motogen that can increase invasiveness and angiogenesis.
Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development.
An essential oligomannosidic glycan chain in the catalytic domain of autotaxin, a secreted lysophospholipase-D.
Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid.
Moreover, recombinant rat autotaxin was found to generate cPA in addition to LPA.
These results indicate that the generation of cPA and LPA in serum is mainly attributed to autotaxin.
L-histidine inhibits production of lysophosphatidic acid by the tumor-associated cytokine, autotaxin.
Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid.
Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors.
The abundance of autotaxin (ATX), a secretory lysoPLD, was also estimated for each fraction.
Following neurotrauma, autotaxin is strongly up-regulated in reactive astrocytes adjacent to the lesion.
In the adult brain, autotaxin is solely expressed in leptomeningeal cells and oligodendrocyte precursor cells.
Functional invalidation of the autotaxin gene by a single amino acid mutation in mouse is lethal.